Unveiling structure-activity correlations is essential in catalysis science. Here, the authors report the structural evolution of Ni-based pre-catalysts during the reaction and demonstrate how sub-nanometric variations affect catalytic performance in the electrocatalytic oxygen evolution reaction.

Spin-to-charge interconversion is a foundational requirement for spin-based electronics. Herein, Victor et al explore spin-pumping in MoS₂, and reveal two spin-pumping channels arising from the metallic edge and semiconducting bulk respectively.

Inspired from bimetallic active sites in both enzymes and heterogeneous catalysts, the development of binuclear catalysis can offer the potential to induce novel intermediates, reactivity, and selectivity. Here the authors report a dimerization-hydrocarbofunctionalization of internal alkynes via dinickel catalysis, leading to the formation of pentasubstituted 1,3-dienes.

Chung et al. show that total-body dynamic positron emission tomography can allow non-invasive quantitative imaging of the molecular permeability of the human blood-brain barrier using various molecular radiotracers.

In contrast to the rich chemistry of porphyrin, the structural variety of phthalocyanine derivatives, which are widely utilized in material and life sciences, has been limited by the lack of versatile synthetic methods. Here, the authors report a synthetic strategy for the meso-position editing of nickel(II)-containing phthalocyanine derivatives.

This study evaluated the success of marine ecosystem restoration efforts through a descriptive statistical comparison, a formal meta-analysis conducted on 764 active restoration interventions, and by using a mixed model based on a spectrum of survival data reported in the reviewed literature.

Biosignatures based on Earth-like metabolism might miss alien life. The authors’ minimal model shows that self-replication with ecological competition naturally produces spatially ordered energy gradients in chemical resources—providing an agnostic signature of life.

A high-resolution astrochronological framework for the early Ediacaran refines the timing of key events, linking glaciation, carbon isotope excursions, and fossil assemblages to gradual ecosystem complexity and rapid biogeochemical transitions.

Enhanced weathering of basalt (EW) removes CO2 chemically, and biotically by enhancing ecosystem growth through phosphorus release. This study shows that leveraging the biotic process can triple the contribution of EW to climate change mitigation.

Efficient and stable heterogeneous catalysts for sustained oxidant activation are vital for solving the global water crisis but elusive. Here, the authors explore the in situ dynamic reconstruction of graphitic carbon nitride photocatalysts with iodine redox mediators, to develop a solar-driven Fenton-like system that activates periodate for effective and sustainable wastewater regeneration.

Bacterial genomes still contain many hidden and uncharacterized genes. Using complementary Ribo-seq approaches, Froschauer, Svensson et al. here annotate start and stop codons of Campylobacter jejuni, reporting a high-resolution translatome and identifying several novel small ORFs in this foodborne pathogen.

The lysosomal enzyme beta-glucocerebrosidase is a key player and promising therapeutic target in Parkinson’s disease. Here, Dobert et al. leveraged cryo-EM to solve the protein structure of the enzyme in complex with its lysosomal transporter LIMP-2.

This study proposes an unreported molecular mechanism of substrate inhibition in enzymes. It shows that a competitive inhibitor reduces substrate inhibition and identifies unique enzyme-substrate complexes, suggesting an unreported paradigm for enzyme regulation.

Current theories of bacterial growth physiology often lack mechanistic detail. Here, Droghetti et al. present a theoretical framework that includes sensing and regulation of protein synthesis at the mRNA level, showing that the sensing-regulatory interplay gives rise to oscillatory responses to external changes.

Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and suggest this strategy, termed directSLiMs, could be used to inhibit other “undruggable” enzymes.

Chung et al. show that total-body dynamic positron emission tomography can allow non-invasive quantitative imaging of the molecular permeability of the human blood-brain barrier using various molecular radiotracers.

The lysosomal enzyme beta-glucocerebrosidase is a key player and promising therapeutic target in Parkinson’s disease. Here, Dobert et al. leveraged cryo-EM to solve the protein structure of the enzyme in complex with its lysosomal transporter LIMP-2.

The DNA methylation landscape of triple-negative breast cancer remains to be characterised. Here, the authors analyse tumour methylome profiles and the genomic context of CpG methylation and identify two epigenetic subtypes with distinct transcriptional patterns.

Lung and gastrointestinal diseases often occur together. Here, the authors present a multi-ancestry study showing the shared genetic architecture between lung and gastrointestinal diseases.

MASLD is a growing global health concern. Here, the authors define a senescent hepatocyte gene signature (SHGS), demonstrate its clinical relevance, and identify senolytic therapies that selectively eliminate SHGS+ hepatocytes to improve MASLD and systemic health.

Enhanced weathering of basalt (EW) removes CO2 chemically, and biotically by enhancing ecosystem growth through phosphorus release. This study shows that leveraging the biotic process can triple the contribution of EW to climate change mitigation.

Achieving the Paris Agreement’s climate goals depends on safeguarding and monitoring the permanence of forest carbon stocks, as delays in addressing their vulnerability to disturbances drastically increase mitigation costs and efforts.

The paper maps air pollution from power plants supplying electricity to US Bitcoin mines. It finds that 1.9 million people in 2022-2023 breathed toxic amounts of Bitcoin mine attributable pollution, particularly around New York City and Houston.

This paper develops a CH₄ emission database for China’s oil and gas systems from 1990 to 2022. It reveals that national emissions surged from 0.5 Tg to 4.0 Tg, mainly due to increased natural gas demand during the energy transition.

Urban populations ebb and flow as the pulse of human mobility reshapes the cityscape. This paper shows a spatiotemporal scaling laws revealing hidden patterns in these dynamic shifts, linking them to the urban fabric’s structure, density, and functionality.