Elsevier

Oral Oncology

Volume 33, Issue 5, September 1997, Pages 291-301
Oral Oncology

Review
Oral leukoplakia: a Clinicopathological review

https://doi.org/10.1016/S1368-8375(97)00002-XGet rights and content

Abstract

Leukoplakia is the most common premalignant or potentially malignant lesion of the oral mucosa. It seems preferable to use the term leukoplakia as a clinical term only. When a biopsy is taken, the term leukoplakia should be replaced by the diagnosis obtained histologically. The annual percentage of malignant transformation varies in different parts of the world, probably as a result of differences in tobacco and dietary habits. Although epithelial dysplasia is an important predictive factor of malignant transformation, it should be realized that not all dysplastic lesions will become malignant. On the other hand non-dysplastic lesions may become malignant as well. In some parts of the world the tongue and the floor of the mouth can be considered to be high-risk sites with regard to malignant transformation of leukoplakia, while this does not have to be the case in other parts of the world. The cessation of tobacco habits, being the most common known aetiological factor of oral leukoplakia, has been shown to be an effective measure with regard to the incidence of leukoplakia and, thereby, the incidence of oral cancer as well. Screening for oral precancer may be indicated in individuals at risk.

References (139)

  • T.E. Daniels et al.

    Histopathology of smokeless tobacco lesions in professional baseball players. Association with different types of tobacco

    Oral Surgery, Oral Medicine, Oral Pathology

    (1992)
  • P.J. Slootweg et al.

    Verrucous hyperplasia or verrucous carcinoma. An analysis of 27 patients

    Journal of Maxillofacial Surgery

    (1983)
  • H. Lumerman et al.

    Oral epithelial dysplasia and the development of invasive squamous cell carcinoma

    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Endod

    (1995)
  • L.M. Abbey et al.

    Intraexaminer and interexaminer reliability in the diagnosis of oral epithelal dysplasia

    Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology Endod

    (1995)
  • R. Kannan et al.

    Transforming growth factor-alpha overexpression in proliferative verrucous leukoplakia and oral squamous cell carcinoma. An immunohistochemical study

    Oral Surgerv, Oral Medicine, Oral Pathology, Oral Radiology Endod

    (1996)
  • M. Abdel-Salam et al.

    Which oral white lesions will become malignant? An image cytometric study

    Oral Surgery Oral Medicine Oral Pathology

    (1990)
  • Y. Kinoshita et al.

    Diagnostic significance of nuclear DNA content and nuclear area in oral hyperplasia, dysplasia, and carcinoma

    Journal of Oral Maxillofacial Surgery

    (1992)
  • L.R. Eversole et al.

    c-myc oncoprotein expression in oral precancerous and early cancerous lesions

    Oral Oncology, European Journal of Cancer

    (1993)
  • R.G. Steinbeck et al.

    DNA content and PCNA immunoreactivity in oral precancerous and cancerous lesions

    Oral Oncology, European Journal of Cancer

    (1993)
  • W.Y-F. Huang et al.

    Histopathological evaluation of proliferating cell nuclear antigen (PC 10) in oral epithelial hyperplasia and pre malignant lesions

    Oral Surgery, Oral Medicine, Oral Pathology

    (1994)
  • S.C. Girod et al.

    p53 and Ki 67 expression in preneoplastic and neoplastic lesions of the oral mucosa

    International Journal of Oral Maxillofacial Surgery

    (1993)
  • P.B. Sugerman et al.

    Heat shock protein expression in oral epithelial dysplasia and squamous cell carcinoma

    Oral Oncology, European Journal of Cancer

    (1995)
  • M.A. Kahn et al.

    Proliferative verrucous leukoplakia. Four cases with flow cytometric analysis

    Oral Surgery Oral Medicine, Oral Pathology

    (1994)
  • T. Axéll et al.
  • T. Axéll et al.

    International seminar on oral leukoplakia and associated lesions related to tobacco habits

    Comrnunity Dental and Oral Epidemiology

    (1984)
  • I.R.H. Kramer et al.

    WHO Collaborating Centre for Oral Precancerous Lesions, Definition of leukopakia and related lesions: an aid to studies on oral precancer

    Oral Surgery, Oral Medicine, Oral Pathology

    (1978)
  • EC Clearinghouse on oral problems related to HIV infection and WHO Collaborating Centre on oral manifestations of the immunodeficiency virus. Classification and diagnostic criteria for oral lesions in HIV infection

    Journal of Oral Pathology and Medicine

    (1993)
  • I. Waal van der

    Letter to the Editor. Greenspan lesion is a better term than oral “hairy” leukoplakia

    Journal of Oral Pathology and Medicine

    (1996)
  • F.S. Mehta et al.

    Tobacco-related oral mucosal lesions and conditions in India. A guide for dental students, dentists, and physicians

    (1993)
  • A.M. Idris et al.

    Toombak-associated oral mucosal lesions in Sudanese show a low prevalence of epithelial dysplasia

    Journal of Oral Pathology and Medicine

    (1996)
  • Å. Larsson et al.

    Reversibility of snuff dipper's lesion in Swedish moist snuff users: a clinical and histological follow-up study

    Journal of Oral Pathology and Medicine

    (1991)
  • G.E. Kaugars et al.

    The prevalence of oral lesions in smokeless tobacco users and an evaluation of risk factors

    Cancer

    (1992)
  • P.C. Gupta

    A study of dose-response relationship between tobacco habits and oral leukoplakia

    British Journal of Cancer

    (1984)
  • B. Roed-Petersen

    Effect on oral leukoplakia of reducing or increasing tobacco smoking

    Acta Dermatolvener

    (1981)
  • World Health Organization

    Report from a meeting of investigators on the histological definition of precancerous lesions

    (1973)
  • P.C. Gupta et al.

    Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow-up study of Indian villagers

    Community Dental and Oral Epidemiology

    (1980)
  • S. Silverman et al.

    Malignant transformation and natural history of oral leukoplakia in 57,518 industrial workers of Gujarat, India

    Cancer

    (1976)
  • J. Bánóczy et al.

    Longitudinal studies in oral leukoplakias

    Journal of Oral Pathology

    (1972)
  • S. Silverman et al.

    Oral leukoplakia and malignant transformation. A follow-up study of 257 patients

    Cancer

    (1984)
  • P.O. Lind

    Malignant transformation in oral leukoplakia

    Scandinavian Journal of Dental Research

    (1987)
  • L. Tischendorf et al.

    Studien zur Dignität der Leukoplakie yon Mundschleimhaut and Lippen

    Deutsche Zeitschrift für Mund-, Kiefer-, and Gesichtschirurgie

    (1990)
  • A. Dunsche et al.

    Die Leukoplakie der Mundschleimhaut— eine retrospektive Studie an 161 Patienten

    Deutsch Zahnärztliche Zeitschrift

    (1992)
  • B. Frerich et al.

    Maligne Transformation oraler Leukoplakien. Eine retrospektieve klinishche and zellproliferationskinetische Studie

    Dtsch Zahnärztl Z

    (1992)
  • K.K.H. Gundlach

    Wieviele Plattenepithelkarzinome der Mundhöhle sind aus Leukoplakien entstanden?

    Deutsche Zeitschrift fur Mund-, Kiefer- and Gesichtschirugie

    (1992)
  • T. Axéll

    Occurrence of leukoplakia and some other white lesions among 20,333 adult Swedish people

    Community Dental and Oral Epidemiology

    (1987)
  • P.C. Gupta

    Leukoplakia and incidence of oral cancer

    Journal of Oral Pathology and Medicine

    (1989)
  • T. Axéll

    A prevalence study of oral mucosal lesions in an adult Swedish population

    Odontologist Revy

    (1976)
  • C.A. Waldron et al.

    Leukoplakia revisited. A clinicopathologic study of 3256 oral leukoplakias

    Cancer

    (1975)
  • P.C. Gupta

    Epidemiologic study of the association between alcohol habits and oral leukoplakia

    Community Dental and Oral Epidemiology

    (1984)
  • W.J. Blot et al.

    Oral cancer and mouthwash

    Journal of the Notional Cancer Institute

    (1983)
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